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Salman Khan to Work With South Director Vamsi Paidipally_我的网站

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A | 研究人员利用人工智能解码基因激活中的关键DNA序列。图片来源：美国加州大学圣迭戈分校官网　　美国加州大学圣迭戈分校研究人员利用高通量DNA测序和人工智能技术，解码了人类基因中一段名为“起始子”的关键DNA序列特征。

B | Salman Khan's last outing Sikandar with South filmmaker AR Murugadoss tanked without a trace. Undeterred by that box office result, the superstar has now lined up a new film with another filmmaker from this neck of the woods, and it is Vamsi Paidipally. Salman Khan to headline According to latest reports from tinsel town, Vamsi Paidipally is all set to direct superstar Salman Khan. The filmmaker has been working on a script that suits the superstar’s stardom and image. Apparently, Vamsi wrote the script keeping Salman in mind. He had narrated the plotline to the actor who then asked the director to develop the idea into a full-bound script. It looks like Salman approved the story and that's when Vamsi started working on it. The director was spotted making multiple visits meeting Salman in Mumbai in recent times. And those in the know, have revealed that star producer Dil Raju is backing the project. Recently, his co-producer Shirish too confirmed the development of Salman’s film. But he hasn’t revealed whether the story is a remake or an original script. Fans are excited to learn about this development, more so, because of the director's strength to showcase his protagonists in a new avatar. Vamsi-Dil Raju collaborative strength So far, Vamsi has directed six films - Munna, Yevadu, Brindavanam, Oopiri, Maharshi and Varisu. Except Oopiri, all the remaining films were bankrolled by Dil Raju – an indication of their collaborative strength. Vamsi has the reputation of a director who likes to experiment with stories. His last film, Varisu, starring superstar Vijay, was critically acclaimed for showcasing Vijay in a new angle. Sources from Tinseltown indicate that if all goes well, the makers are planning to take Salman’s film on floors with a grand launch early next year. The pre-production work is presently in full swing, and the director is giving final touches to the story. Also Read: Ranveer Singh Draws Criticism for His Comment on Kantara。这项成果为解析基因表达调控规律和预测DNA突变影响提供了新工具。相关论文发表于最新一期《基因与发育》杂志。

C | 　　人体不同类型的细胞虽然拥有基本相同的DNA，但由于被激活的基因不同，最终能够形成不同的细胞类型，并执行各自特定的功能。DNA中的一些特殊片段负责精细调控基因表达，使细胞产生酶、激素、蛋白质以及维持细胞结构和功能所需的其他重要成分。如果这些基因没有被正确激活，细胞可能无法正常发挥功能，并可能引发包括癌症在内的多种疾病。　　为了进一步弄清DNA中哪些序列负责启动基因表达，研究人员将目光投向了“起始子”。这是基因表达过程中的一个重要DNA区域，是基因编码的信息开始被表达，进而产生具有功能产物的关键区域。　　研究人员利用高通量DNA测序技术，检测了约50万个不同“起始子”序列的基因表达活性。随后，他们将这些实验数据用于训练机器学习模型，使AI能够识别“起始子”特有的DNA序列模式。　　利用训练出的模型，研究人员进一步在人体基因中搜索“起始子”的特征序列，发现约60%的人类基因含有“起始子”。他们表示，这些AI模型首次能够预测人类基因中是否存在“起始子”，并解码其DNA碱基序列模式。相关数据和模型还可用于预测“起始子”相关DNA突变的影响，以及设计具有特定功能的合成启动子，即能够调控基因开启和关闭的DNA序列。　　研究人员表示，人类每个细胞中都包含约60亿个DNA碱基，其中蕴含着决定基因何时、何地，以及以多大程度表达的复杂“密码”。此次建立的“起始子”AI模型只是解析这一基因表达“密码”的一小部分，希望未来进一步扩大模型范围，以更加全面地解析人类基因表达调控规律。